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  • Title: SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing beta-lactamases.
    Author: Queenan AM, Shang W, Schreckenberger P, Lolans K, Bush K, Quinn J.
    Journal: Antimicrob Agents Chemother; 2006 Oct; 50(10):3485-7. PubMed ID: 17005839.
    Abstract:
    Imipenem-resistant Serratia marcescens isolates were cultured from a lung transplant patient given multiple antibiotics over several months. The strains expressed SME-3, a beta-lactamase of the rare SME carbapenem-hydrolyzing family. SME-3 differed from SME-1 by a single amino acid substitution of tyrosine for histidine at position 105, but the two beta-lactamases displayed similar hydrolytic profiles.
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