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  • Title: Microdosimetric measurements and estimation of human cell survival for heavy-ion beams.
    Author: Kase Y, Kanai T, Matsumoto Y, Furusawa Y, Okamoto H, Asaba T, Sakama M, Shinoda H.
    Journal: Radiat Res; 2006 Oct; 166(4):629-38. PubMed ID: 17007551.
    Abstract:
    The microdosimetric spectra for high-energy beams of photons and proton, helium, carbon, neon, silicon and iron ions (LET = 0.5-880 keV/microm) were measured with a spherical-walled tissue-equivalent proportional counter at various depths in a plastic phantom. Survival curves for human tumor cells were also obtained under the same conditions. Then the survival curves were compared with those estimated by a microdosimetric model based on the spectra and the biological parameters for each cell line. The estimated alpha terms of the liner-quadratic model with a fixed beta value reproduced the experimental results for cell irradiation for ion beams with LETs of less than 450 keV/microm, except in the region near the distal peak.
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