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  • Title: Observation of single-stranded DNA on mica and highly oriented pyrolytic graphite by atomic force microscopy.
    Author: Adamcik J, Klinov DV, Witz G, Sekatskii SK, Dietler G.
    Journal: FEBS Lett; 2006 Oct 16; 580(24):5671-5. PubMed ID: 17007844.
    Abstract:
    Atomic force microscopy was used to image single-stranded DNA (ssDNA) adsorbed on mica modified by Mg(2+), by 3-aminopropyltriethoxysilane or on modified highly oriented pyrolytic graphite (HOPG). ssDNA molecules on mica have compact structures with lumps, loops and super twisting, while on modified HOPG graphite ssDNA molecules adopt a conformation without secondary structures. We have shown that the immobilization of ssDNA under standard conditions on modified HOPG eliminates intramolecular base-pairing, thus this method could be important for studying certain processes involving ssDNA in more details.
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