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  • Title: Extramedullary haematopoiesis in liver of sudden infant death cases.
    Author: Töro K, Hubay M, Keller E.
    Journal: Forensic Sci Int; 2007 Jul 20; 170(1):15-9. PubMed ID: 17008039.
    Abstract:
    AIMS: To determine the frequency of extramedullary haematopoiesis (EMH) in sudden infant death and control cases, and to provide descriptive data on extramedullary haematopoietic islands and diffuse cells. METHODS: The study was carried out in 51 SIDS and 102 non-SIDS cases. Liver-tissue sections were stained with haematoxylin and eosin, and immunohistochemistry was done with streptavidin-biotin-peroxidase complexes by Polyclonal Haemoglobin "A" antibody. The prevalence of data was estimated statistically by Pearson chi-square test, descriptive statistics, and Kruskal-Wallis test. RESULTS: The Pearson chi-square values (CI: 95%; OR: 0.071-0.49; p: 0.0474) show higher frequency of EMH islands in SIDS than in controls. The number of diffuse extramedullary haematopoetic cells was higher in SIDS cases compared to non-SIDS (p=0.017). CONCLUSIONS: EMH is a frequent finding in SIDS cases, and this may be a consequence of anaemia associated with intrauterine hypoxia, or infections.
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