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  • Title: DNA sequence-based detection of group B Streptococcus directly from heart valve tissue in a patient with culture-negative endocarditis.
    Author: Guggisberg K, Parker R, Megran D, Zhang K, Lester W, Elsayed S.
    Journal: Scand J Infect Dis; 2006; 38(10):931-4. PubMed ID: 17008243.
    Abstract:
    A human case of culture-negative bacterial endocarditis is presented where conventional methods failed to determine a microbial aetiology. DNA sequencing performed directly on autopsy heart valve tissue revealed Streptococcus agalactiae (group B streptococcus). To our knowledge, this is the first report of DNA sequence-based detection of this organism directly from a heart valve.
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