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  • Title: Synergism of CAY-1 with amphotericin B and itraconazole.
    Author: De Lucca AJ, Bland JM, Boue S, Vigo CB, Cleveland TE, Walsh TJ.
    Journal: Chemotherapy; 2006; 52(6):285-7. PubMed ID: 17008779.
    Abstract:
    BACKGROUND: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. METHODS: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h. RESULTS: CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy.
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