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  • Title: Surface modification of hydroxyapatite nanocrystals by grafting polymers containing phosphonic acid groups.
    Author: Choi HW, Lee HJ, Kim KJ, Kim HM, Lee SC.
    Journal: J Colloid Interface Sci; 2006 Dec 01; 304(1):277-81. PubMed ID: 17010357.
    Abstract:
    A novel approach for the surface modification of hydroxyapatite (HAp) nanocrystals is described by grafting polymerization of vinyl phosphonic acid (VPA) using a redox initiating system in an aqueous media. Fourier transform infrared (FT-IR) and XRD analyses confirmed the modification reaction on HAp surfaces. Inductively coupled plasma mass spectroscopy (ICP MS) showed that the Ca/P molar ratio decreased from 1.67 to 1.36 with increasing the feed VPA amount. Zeta potentials of unmodified HAp and modified HAp in phosphate-buffered saline (PBS) solutions (pH 7.4, ionic strength = 10 mM) were negative and decreased with increasing the amount of grafted PVPA. Transmission electron microscopy (TEM) measurements and time-dependent phase monitoring indicated that the colloidal stability of modified HAp over unmodified HAp in water dramatically increased and tended to exist as single nanocrystals without aggregation.
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