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  • Title: Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol.
    Author: Lee YS, Jeong JM, Kim YJ, Chang YS, Lee HJ, Son M, Lee JW, Yoon HS, Kang WJ, Lee DS, Chung JK, Lee MC, Suh YG.
    Journal: Appl Radiat Isot; 2007 Jan; 65(1):64-9. PubMed ID: 17010628.
    Abstract:
    A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.
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