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  • Title: Resolution of medically resistant hypothyroidism after liver transplantation for hepatic hemangioendothelioma.
    Author: Lee TC, Barshes NR, Agee EE, O'Mahony CA, Karpen SJ, Carter BA, Bristow JD, Goss JA.
    Journal: J Pediatr Surg; 2006 Oct; 41(10):1783-5. PubMed ID: 17011291.
    Abstract:
    Hepatic hemangioendothelioma (HHE) is a rare vascular tumor in neonates and may cause high-output cardiac failure and coagulopathy, and rarely has been associated with hypothyroidism. Hepatic hemangioendothelioma treatment options consist of corticosteroids, alpha-interferon, surgical resection, and liver transplantation. Herein, we report the case of a 6-week-old female neonate that presented with an HHE that involved all segments of the liver, resulting in respiratory failure and severe hypothyroidism that was recalcitrant to exogenous L-thyroxine therapy. After failure of medical and supportive therapy for the HHE, the patient underwent a cadaveric orthotopic liver transplantation that resulted in successful treatment of the severe hypothyroidism, respiratory failure, and cardiac symptoms. The patient is currently 1-year posttransplantation and disease free with normal thyroid function.
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