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  • Title: An Asian patient with intraocular lymphoma treated by intravitreal methotrexate.
    Author: Wang JK, Yang CM, Lin CP, Shan YD, Lo AY, Tien HF.
    Journal: Jpn J Ophthalmol; 2006; 50(5):474-478. PubMed ID: 17013703.
    Abstract:
    BACKGROUND: To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma. CASE: A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma. OBSERVATIONS: The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up. CONCLUSION: Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma.
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