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  • Title: Flow cytometry as a diagnostic tool for hereditary spherocytosis.
    Author: Stoya G, Gruhn B, Vogelsang H, Baumann E, Linss W.
    Journal: Acta Haematol; 2006; 116(3):186-91. PubMed ID: 17016037.
    Abstract:
    Flow cytometric analysis of eosin-5'-maleimide-labeled red blood cells has been proposed as a new method of identifying hereditary spherocytosis (HS). The aim of the present study was to analyze sensitivity and specificity of this method. Red blood cells from patients with HS (n = 58) revealed significantly lower mean channel fluorescence values than red blood cells from normal subjects (n = 110), unaffected HS family members (n = 8), and patients with other anemias (n = 44). Taking a mean channel fluorescence of 400.0 units as the threshold value identified by logistic regression, sensitivity and specificity of the test for HS were 96.6 and 99.1%, respectively. Flow cytometric analysis is a valuable screening test for the diagnosis of HS.
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