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  • Title: Comparative study on a homemade rapid urease test with gastric biopsy for diagnosis of Helicobacter pylori infection.
    Author: Makaju RK, Tamang MD, Sharma Y, Sharma N, Koju R, Bedi TR, Khanal S.
    Journal: Nepal Med Coll J; 2006 Jun; 8(2):97-100. PubMed ID: 17017398.
    Abstract:
    The main objective of this study was to determine whether a homemade rapid urease test was reliable when compared to histology in the diagnosis of Helicobacter pylori infection. Endoscopic antral biopsies from 15th August 2004 to 15th July 2005 were studied prospectively. Rapid urease test and histological examination were done on all specimens. Among 160 biopsies, 56 cases showed H. pylori in histological section and 59 cases were rapid urease test positive. Among 56 H. pylori infected patients, the sensitivity, specificity, positive and negative predictive values, percentage of false positive, and percentage of false negative values of rapid urease test were 96.4%, 95.2%, 91.5%, 98.0%, 4.8% and 3.5% respectively. Rapid urease test is positive in significantly higher number (p < 0.001) in histological positive cases. In conclusion our homemade rapid urease test is a test with good sensitivity and specificity for detection of H. pylori infection.
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