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  • Title: [Is there a future for vaccines against gastrointestinal helminths?].
    Author: Bos HJ, Schetters T.
    Journal: Tijdschr Diergeneeskd; 1990 Dec 01; 115(23):1102-10. PubMed ID: 1701926.
    Abstract:
    Vaccines against gastro-intestinal helminths have a large market potential, but they also generally have a narrow range of activity. This is a major drawback in the competition with the broad-spectrum anthelmintics and there is still a long way to go before molecular (recombinant) vaccines will appear on the market. Major problems are the induction of protective gut-mucosal immunity with subunit vaccines and the differences in genetic background within host populations, which largely determine the efficacy of vaccination. As yet the changes for vaccines against blood- and tissue parasites, comprising a number of veterinary important protozoa, seem to be better.
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