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  • Title: Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway.
    Author: Koketsu K, Oguri H, Watanabe K, Oikawa H.
    Journal: Org Lett; 2006 Oct 12; 8(21):4719-22. PubMed ID: 17020286.
    Abstract:
    [reaction: see text] Little is known about how quinoxaline-2-carboxylic acid (QC) is synthesized in nature. On the basis of analysis of echinomycin biosynthetic gene clusters as well as feeding experiments with labeled precursors, we have proposed a biosynthetic pathway to QC and identified the (2S,3S)-beta-hydroxytryptophan as a key intermediate.
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