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  • Title: Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton.
    Author: Han QB, Cheung S, Tai J, Qiao CF, Song JZ, Tso TF, Sun HD, Xu HX.
    Journal: Org Lett; 2006 Oct 12; 8(21):4727-30. PubMed ID: 17020288.
    Abstract:
    [structure: see text] A novel diterpene with an unprecedented tetracyclic 6,7:8,15-di-seco-7,20-olide-6,8-cyclo-ent-kaurane skeleton, named maoecrystal Z (1), has been isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx (Labiatae). Its structure was determined by comprehensive NMR and MS spectroscopic analysis coupled with single-crystal X-ray crystallographic diffraction. Compound 1 exhibited comparable inhibitory effect against human K562 leukemia, MCF7 breast, and A2780 ovarian tumor cells with IC(50) = 2.90, 1.63, and 1.45 microg/mL and with camptothecin and paclitaxel as the positive controls.
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