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  • Title: Total synthesis of topopyrones B and D.
    Author: Tan JS, Ciufolini MA.
    Journal: Org Lett; 2006 Oct 12; 8(21):4771-4. PubMed ID: 17020299.
    Abstract:
    [reaction: see text] We describe a straightforward synthesis of topopyrones B and D, which are potent and selective inhibitors of topoisomerase I. The chemistry should be suitable for additional structure-activity relationship (SAR) work.
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