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  • Title: Synthesis of 3-(aryl)alkenyl-beta-lactams by an efficient application of olefin cross-metathesis on solid support.
    Author: Testero SA, Mata EG.
    Journal: Org Lett; 2006 Oct 12; 8(21):4783-6. PubMed ID: 17020302.
    Abstract:
    [reaction: see text] An efficient cross-metathesis on solid support for the synthesis of beta-lactam analogues of cholesterol absorption inhibitors is described. The applied strategy allows the introduction of diversity in positions 3 and 4 of the beta-lactam ring with excellent 3,4-trans selectivity and complete E selectivity at the C-3 side chain.
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