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  • Title: Preliminary experience with transarterial chemoembolization (TACE) in liver metastases of uveal malignant melanoma: local tumor control and survival.
    Author: Vogl T, Eichler K, Zangos S, Herzog C, Hammerstingl R, Balzer J, Gholami A.
    Journal: J Cancer Res Clin Oncol; 2007 Mar; 133(3):177-84. PubMed ID: 17021903.
    Abstract:
    PURPOSE: To evaluate results in the palliative treatment of patients with liver metastases of uveal malignant melanoma using transarterial chemoembolization (TACE). MATERIALS AND METHODS: Superselective TACE was repeatedly performed in 12 patients with liver metastases of uveal malignant melanoma. Six patients presented with solitary liver metastases (6-12 cm in size) and six patients with oligonodular metastases (n < or = 6). The embolization suspension consisted of a maximum of 10 mg/m(2) Mitomycin C, 10 ml Lipiodol, and an injection of 200-450 mg resorbable microspheres for vascular occlusion. In the follow-up, magnetic resonance imaging was performed in 3-month intervals. RESULTS: The TACE procedure was well tolerated in all patients without any relevant side effects. Three patients responded to TACE with a size reduction of more than 50% (partial response), five patients with stable disease, and four patients with progressive disease with an increase in volume of more than 25%. Mean survival following primary tumor treatment was 32.9 months, and after first embolization 19.5 months. Lower survival rates were recorded for the progressive group (16.5 months). CONCLUSION: Repeated TACE offers a palliative treatment option in patients with oligonodular liver metastases of uveal malignant melanoma.
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