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  • Title: [Hemopoiesis regulation in healthy subjects and in patients with aplastic anemia at high altitudes].
    Author: Mirrakhimov MM, Raimzhanov AR.
    Journal: Vestn Akad Med Nauk SSSR; 1990; (9):41-7. PubMed ID: 1702250.
    Abstract:
    The paper deals with effects of high-altitude (3200 m) adaptation on the clinical presentation, hemopoiesis, proliferation and differentiation of erythroid bone-marrow cells, growth of cultured bone-marrow fibroblasts, iron metabolism, function of the adrenal cortex and T lymphocytes of aplastic anemia patients. The high-altitude adaptation improves the clinical picture, facilitates hemopoiesis and proliferation and maturation of erythroid bone marrow cells, increases the efficacy of the colony-formation of bone marrow cells, intensifies the glucocorticoid function of the adrenal cortex, and produces positive immunological changes in the organism. Repeated courses of mountain-climatic therapy produce a more stable clinicohematological remission and increase the survival and working capacity of patients. Indications of mountain-climatic therapy are presented.
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