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  • Title: Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase.
    Author: Galli U, Oliaro-Bosso S, Taramino S, Venegoni S, Pastore E, Tron GC, Balliano G, Viola F, Sorba G.
    Journal: Bioorg Med Chem Lett; 2007 Jan 01; 17(1):220-4. PubMed ID: 17027267.
    Abstract:
    New dimethylamino truncated squalene ether derivatives containing a different aromatic moiety (phenyl, naphthyl, and biphenyl) or a simple alkyl (n-hexylic) group were synthesized as inhibitors of the oxidosqualene cyclase (OSC) and of the sterol biosynthetic pathway. The activity against human OSC was compared with the activity against the OSCs of pathogenic organisms such as Pneumocystis carinii and Trypanosoma cruzi. The phenyl derivative was the most potent inhibitor of T. cruzi OSC.
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