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  • Title: Nicotine administration enhances conditioned inhibition in rats.
    Author: MacLeod JE, Potter AS, Simoni MK, Bucci DJ.
    Journal: Eur J Pharmacol; 2006 Dec 03; 551(1-3):76-9. PubMed ID: 17027751.
    Abstract:
    The effect of nicotine on conditioned inhibition was examined using a serial feature negative discrimination task. Nicotine (0.35 mg/kg) or vehicle was administered before each of the 16 training sessions. On some trials in each session, a tone was presented and followed by food reward. On other trials, the tone was preceded by a visual stimulus and not reinforced. Nicotine-treated rats exhibited greater discrimination between the two trial types as evidenced by less frequent responding during non-reinforced trials, and learned the discrimination in fewer sessions than vehicle-treated rats. In contrast, there were no group differences in responding during the reinforced trials.
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