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  • Title: Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL-6 signaling.
    Author: Sun W, Snyder M, Levy DE, Zhang JJ.
    Journal: FEBS Lett; 2006 Oct 30; 580(25):5880-4. PubMed ID: 17027757.
    Abstract:
    To achieve maximal transcriptional activity in response to gp130 cytokines, Serine-727 (Ser-727) of Stat3 is phosphorylated. Ser-727 resides in the LPMSP motif, the only conserved sequence among the transcription activation domains of several STATs. We show here that in addition to Ser-727, other residues in this LPMSP motif are also required for Stat3 activity in response to cytokine signaling through regulation of Ser-727 phosphorylation and recruitment of the transcription co-activator CBP/p300 to the promoters of Stat3-target genes for transcription activation. Hence, we have demonstrated a critical role for the whole conserved LPMSP motif in JAK-STAT signaling.
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