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  • Title: Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage.
    Author: Wasserman D, Geijer T, Sokolowski M, Frisch A, Michaelovsky E, Weizman A, Rozanov V, Wasserman J.
    Journal: Eur Neuropsychopharmacol; 2007 Feb; 17(3):230-3. PubMed ID: 17029913.
    Abstract:
    Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n=85). Comparing the presence of SS with SL+LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (chi2=9.054, df=1, p=0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.
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