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  • Title: Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments.
    Author: Carvalho RC, Patti CC, Takatsu-Coleman AL, Kameda SR, Souza CF, Garcez-do-Carmo L, Abílio VC, Frussa-Filho R, Silva RH.
    Journal: Brain Res; 2006 Nov 29; 1122(1):179-83. PubMed ID: 17030027.
    Abstract:
    We investigated the effects of reserpine (0.1-0.5 mg/kg) on the performance of mice in the plus-maze discriminative avoidance task (DAVT), which simultaneously evaluates memory and motor activity. All doses induced memory impairment (increased aversive arm time) but only 0.5 mg/kg reserpine decreased locomotion (entries in enclosed arms). The results suggest that the DAVT evaluation in reserpine-treated mice can be a useful model for studying cognitive deficits accompanied by motor impairments.
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