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  • Title: The treatment of HIV associated thrombocytopenia in haemophiliacs.
    Author: Lim SG, Lee CA, Kernoff PB.
    Journal: Clin Lab Haematol; 1990; 12(3):237-45. PubMed ID: 1703063.
    Abstract:
    HIV associated thrombocytopenia occurs in 5-10% of asymptomatic individuals, and 25-45% of people with AIDS. A variety of treatments are available but the inherited bleeding disorder in addition to the thrombocytopenia makes management in haemophiliacs a special problem. The management of this double coagulopathy is described in seven patients. IV gammaglobulin and steroids were useful only in the short term; zidovudine produced a good response, could be taken orally, had anti-HIV activity and was well tolerated in asymptomatic HIV positive patients. Interferon was an alternative when zidovudine was ineffective or produced intolerable side-effects. Splenectomy was considered only after failure of other treatments because of the increased risks of bleeding.
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