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  • Title: Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells.
    Author: Willaime-Morawek S, Seaberg RM, Batista C, Labbé E, Attisano L, Gorski JA, Jones KR, Kam A, Morshead CM, van der Kooy D.
    Journal: J Cell Biol; 2006 Oct 09; 175(1):159-68. PubMed ID: 17030986.
    Abstract:
    Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells from midgestation into adulthood. Lineage tracing in combination with direct cell labeling and time-lapse video microscopy demonstrated that Emx1-lineage embryonic cortical stem cells migrate ventrally into the striatal germinal zone (GZ) perinatally and intermingle with striatal stem cells. Upon integration into the striatal GZ, cortical stem cells down-regulate Emx1 and up-regulate Dlx2, which is a homeobox gene characteristic of the developing striatum and striatal neural stem cells. This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain.
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