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  • Title: Interferon induction by viruses. XX. Acid-labile interferon accounts for the antiviral effect induced by poly(rI).poly(rC) in primary chick embryo cells.
    Author: Yoshida I, Marcus PI.
    Journal: J Interferon Res; 1990 Oct; 10(5):461-8. PubMed ID: 1703194.
    Abstract:
    Primary chick embryo cells which were "aged" in vitro and exposed to poly(rI).poly(rC) developed a disproportionately high degree of resistance to virus challenge in relation to the amount of conventional acid-stable interferon (IFN) produced. Cells were often highly resistant after exposure to a few nanograms of poly(rI).poly(rC) which gave rise to little or no acid-stable IFN. Study of the mechanism(s) responsible showed that this antiviral state was not due to the double-stranded ribonuclease induced in parallel, nor to residual poly(rI).poly(rC) (which this ribonuclease destroyed), but to the production of a hitherto undescribed acid-labile chicken IFN.
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