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  • Title: Synchronous ovarian granulosa cell tumor and uterine serous carcinoma: a rare association of a high-risk endometrial cancer with anestrogenic ovarian tumor.
    Author: Rabban JT, Gupta D, Zaloudek CJ, Chen LM.
    Journal: Gynecol Oncol; 2006 Dec; 103(3):1164-8. PubMed ID: 17034837.
    Abstract:
    BACKGROUND: Ovarian granulosa cell tumors are often associated with endometrial hyperplasia or carcinoma. The endometrial carcinoma is thought to occur under the influence of the estrogen receptor pathway and is typically a low-grade, low-stage endometrioid adenocarcinoma. CASE: We present a case of a woman with a granulosa cell tumor of the ovary and a synchronous serous carcinoma of the endometrium. Immunohistochemical stains for estrogen receptors, progesterone receptors, and p53 protein were performed on both tumors. CONCLUSIONS: Not all uterine tumors associated with ovarian granulosa cell tumors have low-risk histology. Preoperative evaluation of the uterus with attention to tumor subtyping is important for optimum staging and therapy.
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