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  • Title: Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation.
    Author: Ge WP, Duan S.
    Journal: J Neurophysiol; 2007 Mar; 97(3):2564-9. PubMed ID: 17035364.
    Abstract:
    Neuron-glia signaling is important for neural development and functions. This signaling may be regulated by neuronal activity and undergo modification similar to long-term potentiation (LTP) of neuronal synapses, a hallmark of neuronal plasticity. We found that tetanic stimulation of Schaffer collaterals (Sc) in the hippocampus that induced LTP in neurons also resulted in LTP-like persistent elevation of Sc-evoked slow depolarization in perisynaptic astrocytes. The elevated slow depolarization in astrocytes was abolished by NMDA receptor antagonist and K(+) channel inhibitors, but not by Ca(2+) chelator BAPTA loaded in the recorded astrocytes, suggesting involvement of an increased extracellular K(+) accumulation accompanying LTP of neuronal synapses. The increased K(+) accumulation and astrocyte depolarization after LTP induction may reduce the efficiency of glial glutamate transporters, which may contribute to the enhanced synaptic efficacy. The neuronal activity-induced persistent enhancement of neuron-glia signaling may thus have important physiological relevance.
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