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  • Title: [Influence of blockade of costimulation on Th1/Th2 cytokines shift in unexplained early recurrent spontaneous].
    Author: Fan W, Li SW, Liu XR.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2006 Sep; 37(5):773-5. PubMed ID: 17037749.
    Abstract:
    OBJECTIVE: To assess the influence of blockade of costimulation on Th1/Th2 Cytokines shift in unexplained early recurrent spontaneous abortion (URSA). METHODS: The levels of IL-2, IFN-gamma and IL-4 were determined by ELISA in the supernatant of cultured maternal peripheral blood mononuclear cells (PBMC) from 30 patients of URSA. Cytokine synthesis was induced by activation with antigens from a choriocarcinomer cell line of JEG-3, with CTLA4Ig at concentrations of 10 microg/mL and 1 microg/mL (experiment groups), or with IgG at the same concentrations (control groups). RESULTS: The CTLA4Ig groups showed significantly higher levels of Th2 cytokines IL-4 (P < 0.05), lower levels of Th1 cytokines IL-2 (P < 0.05) and the same levels of IFN-gamma (P > 0.05), compared with the control groups of the same concentrations respectively. The same results were found between the experiment groups of different concentration. CONCLUSION: CTLA4Ig could switch T cell responses from Th1 to Th2 in URSA by blockade of CD80/CD86 costimulation.
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