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  • Title: [Comparative research on the implantation of mouse blastocyst in the co-cultural system of malignant tumor Cells and receptive endometrium in vitro].
    Author: Ma F, Wang ZB, Wang Y, Zhao J.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2006 Sep; 37(5):776-80. PubMed ID: 17037750.
    Abstract:
    OBJECTIVE: Comparaticely to study biological behaviour variability of mouse embryo implantation in vitro between malignant tumor cells and receptive endometrium, on the basis of the co-culture of mouse blastocyst and malignant tumor cells in vitro. METHODS: The light scope, scanning electron scope, the HE and immunohistochemical staining were applied to investigate and observe the blastocyst biology behavior in co-cultural system in vitro of mouse blastocyst-malignant cell and blastocyst-monolayer receptive endometrium. RESULTS: There was no significant biological behaviors observed or discovered for mouse blastocysts to implant into co-cultural system with malignant tumor cells from different histologcial origins, and no significant rates obtained for hatchment, attachment and outgrowth of mouse blastocysts in the co-culture system (P > 0.05) of monolayer receptival endometrium cells and malignant tumor cells. There was no significant difference observed between the cell morphology changes of implanted in endometrium and MMP-9 expressed in trophoblastic cells. CONCLUSIONS: That the mouse blastocyst cells has no biological behaviour difference happened between two co-cultural systems in vitro indicates it may be relevant with its high adaptation to environment and self assembly of the early life.
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