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  • Title: Cross-reactivity among amide-type local anesthetics in a case of allergy to mepivacaine.
    Author: González-Delgado P, Antón R, Soriano V, Zapater P, Niveiro E.
    Journal: J Investig Allergol Clin Immunol; 2006; 16(5):311-3. PubMed ID: 17039671.
    Abstract:
    Among the various adverse reactions to local anesthetics, IgE-mediated reactions, particularly to the more commonly used amide group, are extremely rare. We report the case of a 39-year-old man who suffered itching and generalized urticaria with facial angioedema 15 minutes after administration of mepivacaine. Skin tests revealed a strong positive reaction to mepivacaine, lidocaine, and ropivacaine, but negative reactions to bupivacaine and levobupivacaine. Furthermore, double-blind placebo-controlled subcutaneous challenge with bupivacaine and levobupivacaine was well tolerated. We conclude that an extensive allergologic study must be carried out in rare cases of true allergic reaction to amide-type local anesthetics in order to rule out cross reactivity.
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