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  • Title: A comparative analysis of multi-conductance neuronal models in silico.
    Author: DeWeerth SP, Reid MS, Brown EA, Butera RJ.
    Journal: Biol Cybern; 2007 Feb; 96(2):181-94. PubMed ID: 17043879.
    Abstract:
    We demonstrate that a previously presented flexible silicon-neuron architecture can implement three disparate conductance-based neuron models with both fast and slow dynamics. By exploiting the real-time nature of this physical implementation, we mapped the model dynamics across a large region of parameter space. We also found that two of these dynamically different models represent points in a contiguous bursting space that spans between the two models. By systematically varying the model parameters, we also found that multiple, diverse trajectories in parameter space connected the two canonical bursting points. In addition, we found that the combination of parameter values keeps the neuron in the bursting region. These findings demonstrate the usefulness of the silicon-neuron architecture as a neural-modeling tool and illustrate its versatility as a platform for a multi-behavioral neuron that resembles its living analog.
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