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  • Title: Ochronosis of the aortic valve and aorta.
    Author: Kovacevic M, Simic O, Medved I, Lucin K, Padovan M.
    Journal: J Heart Valve Dis; 2006 Sep; 15(5):730-2. PubMed ID: 17044384.
    Abstract:
    A 64-year-old male patient with unknown alkaptonuria and severe aortic stenosis and ischemic heart disease was admitted to the authors' institution for elective surgery. The patient underwent aortic valve replacement with a 25-mm aortic valve (ATS Medical, Inc.) and single venous aortocoronary artery bypass grafting for a right coronary artery. Aortotomy revealed typical ochronotic pigmentation of a severely calcified aortic valve and aortic intima. A diagnosis of alkaptonuria was confirmed by evidence of homogentisic acid in the patient's urine, together with histopathological analysis.
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