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  • Title: Priming effects of mammalian tachykinins on human neutrophils.
    Author: Brunelleschi S, Tarli S, Giotti A, Fantozzi R.
    Journal: Life Sci; 1991; 48(2):PL1-5. PubMed ID: 1704475.
    Abstract:
    The undecapeptide substance P (SP) is known to activate different cell types involved in inflammatory and immune processes. By evaluating primed stimulation of human neutrophils, we now demonstrate that SP (10 nM-0.1 mM) dose-dependently enhances superoxide anion production from cells stimulated by the phospholipid mediator Platelet Activating Factor (PAF). We also provide evidence that neurokinin A (NKA), which is released, as well as SP, from C fibers of sensory nerves, potentiates PAF-evoked superoxide anion generation, while neurokinin B (NKB) is ineffective.
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