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  • Title: Herpes simplex and Epstein-Barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine.
    Author: Mercadal S, Martinez A, Nomdedeu B, Rozman M, Gaya A, Salamero O, Campo E.
    Journal: Eur J Haematol; 2006 Nov; 77(5):442-4. PubMed ID: 17044837.
    Abstract:
    Multiple herpes virus co-infection is a very rare complication in patients with chronic lymphocytic leukemia (CLL). We describe a patient with a CLL who developed an herpes virus lymphadenitis. Inmunohistochemical study was positive for HSV-1, HSV-2, and Epstein-Barr Virus (EBV). The coinfection of EBV with a profile of expresion of viral latent genes type III, is usually seen in inmunodepressed patients. To the best of our knowledge, this is the first reported case of a multiple human herpes virus infection mimicking Richter syndrome.
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