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  • Title: Synthesis, analytical behaviour and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents.
    Author: Guillon J, Forfar I, Mamani-Matsuda M, Desplat V, Saliège M, Thiolat D, Massip S, Tabourier A, Léger JM, Dufaure B, Haumont G, Jarry C, Mossalayi D.
    Journal: Bioorg Med Chem; 2007 Jan 01; 15(1):194-210. PubMed ID: 17049253.
    Abstract:
    An original series of 4-substituted pyrrolo[1,2-a]quinoxaline derivatives, new structural analogues of Galipea species quinoline alkaloids, was synthesized from various substituted 2-nitroanilines via multistep heterocyclizations and tested for in vitro antiparasitic activity upon Leishmania amazonensis and Leishmania infantum strains. Structure-activity relationships enlighten the importance of the 4-substituted alkenyl side chain on the pyrrolo[1,2-a]quinoxaline moiety to modulate the antileishmanial activity.
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