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  • Title: Complement modulating and anticoagulant effects of a sulfated exopolysaccharide released by the cyanobacterium Synechocystis aquatilis.
    Author: Volk RB, Venzke K, Blaschek W, Alban S.
    Journal: Planta Med; 2006 Dec; 72(15):1424-7. PubMed ID: 17051462.
    Abstract:
    During batch cultivation, the cyanobacterial strain Synechocystis aquatilis Sauvageau B90.79 was found to release a fucose-rich sulfated polysaccharide, which was mainly composed of arabinose (45%) and fucose (47%) and had a degree of sulfation of 0.43. The released polysaccharide showed merely an anticoagulant activity of less than 10% compared to the reference compound, unfractionated heparin. However, distinctive effects on the complement activation were observed: its inhibitory effect on the classical pathway of complement activation was 600-fold stronger than that of unfractionated heparin, whereas that on the alternative pathway of complement activation was 2- to 3-fold weaker. The results indicate that this biotechnologically producible, released polysaccharide represents a specifically acting complement modulator.
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