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  • Title: Pediatric T-cell post-transplant lymphoproliferative disorder after solid organ transplantation.
    Author: Yang F, Li Y, Braylan R, Hunger SP, Yang LJ.
    Journal: Pediatr Blood Cancer; 2008 Feb; 50(2):415-8. PubMed ID: 17051534.
    Abstract:
    Post-transplant lymphoproliferative disorder (PTLD) is the most common treatment related malignancy that occurs after solid organ transplantation (SOT). PTLD has extended from its initial description as an Epstein-Barr virus (EBV)-driven B-cell proliferation to include EBV-negative and non B-lineage cases. T-cell PTLD (T-PTLD) is rare in both adults and children. We report two cases of pediatric T-PTLD after SOT (liver and lungs) and review cases reported in the literature. Both patients had a bimodal response to therapy with initial eradication of bulky nodal disease with regimens typically used to treat leukemia, but persistence of low-level clonal T-cells in marrow, CSF and lung in one case.
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