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  • Title: Strong ion difference excess and corrected strong ion difference model incorporating the variations in apparent dissociation constant for human blood plasma electro-neutrality equilibria.
    Author: Rana AP, Rana SP, Rana JP, Singh S.
    Journal: Indian J Physiol Pharmacol; 2006; 50(2):114-20. PubMed ID: 17051730.
    Abstract:
    We introduce computed value of the corrected Strong Ion Difference (SID) by including the large variability of the apparent dissociation constant pK' in non-logarithmic form on SID in Henderson-Hasselbach bicarbonate ion aqueous equilibria thereby resulting in a significant correction of up to 27% in SID. We further introduce a new concept of Strong Ion Difference Excess (SIDE) as the change in SID from the reference value at pH = 7.4, pCO2 = 5.33 Kpa (or 40 torr). The SIDE is a particularly useful quick measure when one can rule out the effects of hemoglobin, weak proteins and unidentified components for human blood plasma.
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