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  • Title: [Validity of intraoperative administration of dexmedetomidine in a patient with dermatomyositis-derived respiratory failure].
    Author: Ito T, Kusunom S, Kawamoto M, Yuge O.
    Journal: Masui; 2006 Oct; 55(10):1243-6. PubMed ID: 17051985.
    Abstract:
    A 66-year-old female with dermatomyositis and severe respiratory failure from collagen lungs, dependent on domiciliary oxygen therapy, was scheduled for a mastectomy. Anesthesia was induced with dexmedetomidine (DEX) 6 microg x kg(-1) x h(-1) for 10 minutes and maintained at 0.7 microg x kg(-1) x h(-1), along with a target controlled infusion of propofol combined with epidural anesthesia. No narcotic or muscle relaxant was used. The airway was secured using a laryngeal mask airway and spontaneous breathing was preserved. The perioperative course was uneventful without any pulmonary complications. DEX has a certain analgesic property and a mild respiratory depressant effect. Therefore, it is considered useful as a concomitant anesthetic agent for perioperative management of patients with respiratory failure.
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