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  • Title: Comparison of creatinine clearance estimates with routine measured clearance.
    Author: Planet G.
    Journal: Clin Biochem; 2007 Jan; 40(1-2):124-7. PubMed ID: 17052703.
    Abstract:
    OBJECTIVES: Compare GFR estimates (eGFR) calculated by formulas (CG, CGI, MDRD) and creatinine clearance (CrCl), in subgroups based on sex, age, BMI and serum creatinine (Cr). DESIGN AND METHODS: eGFR is calculated with Cockgroft-Gault (CG), CG corrected for ideal or lean weight (CGI), and Modification of Diet in Renal Disease (MDRD) formulas using a compensated kinetic Jaffé method. Comparison of means and correlations relative to CrCl is done with 666 male and female adult subjects in different subgroups. RESULTS: Comparatively to CrCl, most subgroups are best correlated with MDRD, especially with high Cr. However, in men <65 years, a factor of 222, instead of 186 in MDRD formula, is better. CONCLUSIONS: eGFR from MDRD formula, modified for men <65 years, is better correlated to CrCl.
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