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  • Title: A novel isoflavonoid from Millettia puguensis.
    Author: Kapingu MC, Mbwambo ZH, Moshi MJ, Magadula JJ, Cos P, Berghe DV, Maes L, Theunis M, Apers S, Pieters L, Vlietinck A.
    Journal: Planta Med; 2006 Nov; 72(14):1341-3. PubMed ID: 17054049.
    Abstract:
    From the roots of Millettia puguensis (Leguminosae), a novel isoflavonoid (5), 2'-methoxy-4',5'-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3',4'-methylenedioxyisoflavone (3) and 7,2'-dimethoxy-4',5'-methylenedioxyisoflavone (4) were isolated and identified by 1H-, 13C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC50 = 32 microM against Leishmania infantum), and a moderate cytotoxicity for compound 2 (IC50 = 43 microM on MRC-5 cells).
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