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Title: Do sigma factors need help with a meltdown? Author: Saecker RM, Davis CA, Record MT. Journal: Cell; 2006 Oct 20; 127(2):256-8. PubMed ID: 17055426. Abstract: In this issue of Cell, Hsu et al. (2006) report on the binding activity of a variant of the bacterial transcriptional specificity factor sigma (sigma) to promoter DNA. This study demonstrates that the sigma variant induces a large distortion in the transcriptional start site in the absence of core RNA polymerase, raising intriguing new questions about the roles of sigma and core RNA polymerase in transcription initiation.[Abstract] [Full Text] [Related] [New Search]