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  • Title: c-Flip(L) is expressed in undifferentiated mouse male germ cells.
    Author: Giampietri C, Petrungaro S, Coluccia P, Antonangeli F, Paone A, Padula F, De Cesaris P, Ziparo E, Filippini A.
    Journal: FEBS Lett; 2006 Nov 13; 580(26):6109-14. PubMed ID: 17056040.
    Abstract:
    Apoptosis represents a fundamental process during fetal/post-natal testis development. Therefore pro- and anti-apoptotic proteins are essential to regulate testis physiology. c-Flip(L) is a known inhibitor of caspase 8/10 activity; in this study its perinatal expression in mouse male germ cells was investigated. In testis sections and seminiferous tubule whole mount c-Flip(L) was found to be expressed in undifferentiated spermatogonia and to co-localize with germ stem cells markers. In vivo investigations in the vitamin-A deficient mouse, lacking differentiated germ cells, confirmed c-Flip(L) expression in undifferentiated spermatogonia. Further analyses showed Fas expression but no significant caspase 8/10 activity when c-Flip(L) was highly expressed. Altogether these data suggest that c-Flip may control the survival rate of undifferentiated spermatogonia.
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