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  • Title: Automated detection and centring of cryocooled protein crystals.
    Author: Pothineni SB, Strutz T, Lamzin VS.
    Journal: Acta Crystallogr D Biol Crystallogr; 2006 Nov; 62(Pt 11):1358-68. PubMed ID: 17057339.
    Abstract:
    A novel method is presented for the automated recognition of cryocooled macromolecular crystals. The method uses several texture-based image-processing algorithms for automated crystal centring, which are able to cope with a variety of crystal morphologies and illumination conditions. The results combined from different algorithms, together with their estimated standard uncertainties, provide a robust determination of the crystal location and allow an internal assessment of their reliability. The method was coded within the software XREC and showed a good performance on 104 sets of images from various beamlines.
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