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  • Title: Protease-catalyzed synthesis of the tripeptide CCK(26-28), a fragment of CCK-8.
    Author: Meng LP, Joshi R, Eckstein H.
    Journal: Amino Acids; 2007 Jul; 33(1):91-6. PubMed ID: 17058117.
    Abstract:
    Two enzymatically synthetic strategies of the tripeptide derivative PhAc-Asp(OMe)-Tyr-Met-OAl are reported. The second strategy gains the advantage of more economical starting materials, less reaction steps and a higher overall isolated yield of this tripeptide fragment over the first strategy. The effect of the acyl-donor ester concentration and structure, the C-alpha protecting group of the nucleophile, reaction media, enzyme and the carrier on the tripeptide derivative synthesis were studied. This tripeptide selected is a fragment of the cholecystokinin C-terminal octapeptide (CCK-8), a potential therapeutic agent in the control of gastrointestinal function and also a drug candidate for the treatment of epilepsy.
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