Title: [Regulatory effects of yiqi zishen granule on helper T-lymphocyte subsets in IgA nephropathy patients]. Author: Yu DJ, Nie LF, Xu YG. Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi; 2006 Sep; 26(9):836-8. PubMed ID: 17058837. Abstract: OBJECTIVE: To study the pathogenesis of IgA nephropathy (IgAN) and the effect of Yiqi Zishen Granule (YZG) on the helper T-lymphocyte subsets Th1/Th2 in IgAN patients. METHODS: Intracellular cytokines secreted by Th1/Th2 were measured using flow cytometry in 24 healthy subjects and 31 IgAN patients treated by YZG before and after treatment. RESULTS: Level of interferon-gamma (IFN-gamma) was lower (P < 0.05) and levels of interleukin 4 (IL-4) and interleukin 10 (IL-10) were higher (P < 0.01) in the IgAN patients than those in the healthy controls, showing imbalance of Th1/Th2 in the IgAN patients. After YZG treatment, the level of IFN-gamma increased and IL-10 level decreased (P < 0.01). CONCLUSION: Imbalance of Th1/Th2 exists in IgAN patients. YZG has a regulatory effect on imbalance of Th1/Th2 in IgAN patients.[Abstract] [Full Text] [Related] [New Search]
