These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Magnesium sulphate reduces cell volume in physiological conditions but not in the cytotoxic oedema during global brain ischemia.
    Author: Chacón A, Lisott E, Eblen-Zajjur A.
    Journal: Brain Inj; 2006 Sep; 20(10):1087-91. PubMed ID: 17060142.
    Abstract:
    PRIMARY OBJECTIVE: To establish the effect of MgSO4 on brain cellular volume during physiological and global ischemia using impedanciometric method. RESEARCH DESIGN: Impedanciometric measure in the brain before and during global brain ischemia, with or without intravenous infusion of MgSO4. METHODS AND PROCEDURES: Male Sprague-Dawley rats were anaesthetized (thiobarbital, 60 mg kg-1 i.p.). Ringer solution (n=9) or MgSO4 (n=8; 1 mmol Kg-1) where i.v. isovolumetrically administered. Sub-cortical impedance was recorded before and after the infusion of ringer or MgSO4 and during global cerebral ischemia induced by a cardiopulmonary arrest. MAIN OUTCOMES AND RESULTS: In non-ischemic conditions, MgSO4 infusion induced higher voltage values than those of ringer infusion (Wilcoxon, Z=2.49; p=0.01). During global cerebral ischemia, the MgSO4 infused animals showed a fast drop of voltages (82%) in the first 5 minutes, 4-fold the values of ringer infused animals (p<0.0001). In the following 15 minutes no differences were found between ringer and MgSO4 infused animals. CONCLUSIONS: The results suggest that MgSO4 significantly reduced brain cell volume in physiological conditions but not in global brain ischemia.
    [Abstract] [Full Text] [Related] [New Search]