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  • Title: Response of intrathecal baclofen resistance to dose reduction.
    Author: Cooper JA, Ridley B.
    Journal: Neurology; 2006 Oct 24; 67(8):1495-6. PubMed ID: 17060585.
    Abstract:
    Dose stabilization of intrathecal baclofen (ITB) is usually achieved within 6 to 18 months. In some patients, an increase in ITB dose may result in paradoxical unresponsiveness to baclofen. We present two cases demonstrating increased tone and functional decline with increasing ITB doses after a period of clinical stability. In both cases, reduction of ITB dose was associated with marked clinical improvement.
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